Key result
Elevated serum uric acid levels were significantly associated with higher blood pressure across different phenotypes and a 26% increased risk of developing new left ventricular hypertrophy per 1 mg/dl increase.
Why the study?
The study examined published and unpublished PAMELA study data on the relationships between serum uric acid, office and out-of-office blood pressure, and organ damage.
Is serum uric acid associated with hypertensive phenotypes and the development of target organ damage?
Is serum uric acid associated with hypertensive phenotypes and the development of target organ damage?
Odds Ratio: 1.26
Data from the PAMELA study demonstrate that elevated serum uric acid is closely associated with various hypertensive phenotypes and independently predicts the development of new hypertension and left ventricular hypertrophy.
PURPOSE OF REVIEW: To examine published and unpublished data collected in the context of the Pressioni Arteriose Monitorate E Loro Associazioni (PAMELA) study on the relationships between serum uric acid (SUA), office and out-of-office blood pressure (BP), and organ damage. RECENT FINDINGS: SUA values were directly and significantly related to a large number of covariates that participate at cardiovascular risk determination, such as blood glucose, total serum cholesterol, serum triglycerides, body mass index, and serum creatinine. Additional variables included echocardiographically-determined left ventricular mass index and BP values, the latter not just when measured in the office but also when evaluated at home or over the 24-h period. White-coat hypertension and masked hypertension were characterized, as sustained hypertension, by a significant increase in SUA levels, which were also directly related to different indices of 24-h BP variability. No substantial difference in SUA levels was found when data were analyzed according to the dipping or non-dipping nocturnal BP profile. Data collected in the frame of the PAMELA study document the presence of a close relationship between SUA levels and BP values independently on the hypertensive phenotype patterns of BP increase (office, 24 h, or both) and nighttime BP profile. They also document the increase in SUA as a potential factor favoring the occurrence of new hypertension and new left ventricular hypertrophy.
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Grassı et al. (2022) conducted a review in Hypertension and Cardiovascular Risk (n=2,051). Serum uric acid (SUA) vs. Lower serum uric acid levels was evaluated on New left ventricular hypertrophy (OR 1.26). Elevated serum uric acid levels were significantly associated with higher blood pressure across different phenotypes and a 26% increased risk of developing new left ventricular hypertrophy per 1 mg/dl increase.
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