Key result
Circulating Lp(a) levels were investigated for causal effects on atherosclerotic, cerebrovascular, thrombotic, and valvular diseases using Mendelian randomization, but results were not reported.
Why the study?
Do circulating Lp(a) levels causally affect atherosclerotic, cerebrovascular, thrombotic, valvular, and Alzheimer diseases in the UK Biobank cohort?
Observational
Do circulating Lp(a) levels causally affect atherosclerotic, cerebrovascular, thrombotic, valvular, and Alzheimer diseases in the UK Biobank cohort?
This Mendelian randomization study investigates the causal role of Lp(a) in various cardiovascular, thrombotic, and neurological diseases using the UK Biobank cohort.
heart valve diseases lipoprotein(a) Mendelian randomization analysis stroke L ipoprotein(a) (Lp[a]) is a circulating lipoprotein with proatherogenic, proinflammatory, and possibly prothrombotic properties. Circulating Lp(a) levels are largely genetically determined, in particular, by the LPA gene. As such, genetic variants at the LPA locus can serve as instrumental variables for investigating the clinical effects of circulating Lp(a) levels. 3] Whether Lp(a) is causally related to thrombotic disease and cerebrovascular disease remains unclear. n this study, we used the UK Biobank cohort to perform an MR investigation into the causal effects of circulating Lp(a) levels on atherosclerotic, cerebrovascular, thrombotic, and valvular diseases. Because a recent MR study provided evidence of an inverse association of Lp(a) levels with Alzheimer disease,
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Larsson et al. (2020) conducted an observational in Atherosclerotic, cerebrovascular, thrombotic, and valvular diseases. Circulating Lp(a) levels was evaluated on Atherosclerotic, cerebrovascular, thrombotic, and valvular diseases. Circulating Lp(a) levels were investigated for causal effects on atherosclerotic, cerebrovascular, thrombotic, and valvular diseases using Mendelian randomization, but results were not reported.
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