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February 6, 2013New England Journal of MedicineOpen Access

Genetic Associations with Valvular Calcification and Aortic Stenosis

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Why the study?

Is genetic variation in the LPA locus associated with the presence of aortic-valve calcification and incident aortic stenosis?

Population

6,942 participants of white European ancestry for aortic-valve calcification and 3,795 for mitral annular…

Comparison

Genetic variation in the lipoprotein locus and… vs Absence of the risk allele / alternative genotypes

Design

Cohort

Authors

GTGeorge ThanassoulisPreventive CardiologyCCCatherine Y. CampbellColorado Permanente Medical GroupDODavid S. OwensGeneral Cardiology

Discussion

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Implication

Lp(a) variants linked to aortic stenosis; leaves open whether Lp(a) lowering prevents progression.

Structured PICO

Is genetic variation in the LPA locus associated with the presence of aortic-valve calcification and incident aortic stenosis?

P
Population
6,942 participants of white European ancestry for aortic-valve calcification and 3,795 for mitral annular calcification from three cohorts (discovery population), with replication in independent white European, African-American, Hispanic-American, Swedish, and Danish cohorts.
I
Intervention
Genetic variation in the lipoprotein(a) (LPA) locus (specifically SNP rs10455872) and genetically determined Lp(a) levels
C
Comparator
Absence of the risk allele / alternative genotypes
O
Outcome
Presence of aortic-valve calcification and mitral annular calcification as detected by computed tomographic (CT) scanningsurrogate

Genetic variation in the LPA locus, mediated by Lp(a) levels, is strongly associated with aortic-valve calcification and incident clinical aortic stenosis, supporting a causal role for Lp(a) in valvular heart disease.

Cite This Study

Thanassoulis et al. (2013) studied this question.

synapsesocial.com/papers/6a7dd5dcd491aa75eb1511a5https://doi.org/10.1056/nejmoa1109034

Topics

Valvular heart disease
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