What question did this study set out to answer?

This research investigates the relationship between morning platelet aggregability and the risk of myocardial infarction and sudden cardiac death.

June 11, 1987New England Journal of Medicine

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Healthy (n=15). Intervention: Morning arising vs. Remaining supine and inactive (before arising). Primary outcome: Lowest concentration of ADP required to produce biphasic platelet aggregation (microM) (p=<0.01).

View Full Paper

Ask AI

Bookmark

Key result

Morning arising was associated with a significant increase in platelet aggregability, with the concentration of ADP required for aggregation decreasing from 4.7 to 3.7 microM (P<0.01).

Authors

GTGeoffrey H. ToflerBroad Institute DBDamian A. BrezinskiDuke University ASAndrew I. SchaferNova Southeastern University

Discussion

Member takes

Implication

Morning platelet rise upon arising may underlie circadian MI/SCD peaks; hypothesis-generating and requires clinical validation before any practice implications.

Key Points

This research investigates the relationship between morning platelet aggregability and the risk of myocardial infarction and sudden cardiac death.
Measured platelet activity at 3-hour intervals for 24 hours in 15 healthy men.
Examined platelet responsiveness to adenosine diphosphate and epinephrine at 6 a.m. and 9 a.m.
Studied 10 subjects on alternate mornings under different activity conditions.
Platelet aggregability significantly increased from 6 a.m. to 9 a.m. (P<0.01).
The lowest concentration of ADP required for aggregation decreased from 4.7 to 3.7 microM (P<0.01).
The lowest concentration of epinephrine required for aggregation decreased from 3.7 to 1.8 microM (P<0.01).

Study Design

Type

Observational (n=15)

PICO

Population

15 healthy men who underwent 24-hour monitoring of platelet activity to assess morning changes in aggregability.

Exposure / Comparator

Morning arising vs Remaining supine and inactive (before arising)

Primary Outcome

Lowest concentration of ADP required to produce biphasic platelet aggregation (microM), p=<0.01

Main Result

Absolute Event Rate: 3.7% vs 4.7%

p-value: p=<0.01

Limitations

Demonstration of this association does not establish a cause-effect relation between increased platelet aggregability and myocardial infarction or sudden cardiac death.

Cite This Study

Tofler et al. (1987) conducted an observational in Healthy (n=15). Morning arising vs. Remaining supine and inactive (before arising) was evaluated on Lowest concentration of ADP required to produce biphasic platelet aggregation (microM) (p=<0.01). Morning arising was associated with a significant increase in platelet aggregability, with the concentration of ADP required for aggregation decreasing from 4.7 to 3.7 microM (P<0.01).

synapsesocial.com/papers/6a64b03cebf08ab368f01144 https://doi.org/10.1056/nejm198706113162405

View Full Paper

Ask AI

Bookmark

Implication

Morning platelet rise upon arising may underlie circadian MI/SCD peaks; hypothesis-generating and requires clinical validation before any practice implications.

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Limitations

Cite This Study

Concurrent Morning Increase in Platelet Aggregability and the Risk of Myocardial Infarction and Sudden Cardiac Death

Discussion

Member takes

Implication

Key Points

Study Design

PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider