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December 5, 2017MoleculesOpen Access

Lipoprotein Lipase Expression in Chronic Lymphocytic Leukemia: New Insights into Leukemic Progression

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Key result

Lipoprotein lipase expression in tumor cells is linked to poor clinical outcomes in patients with chronic lymphocytic leukemia, though its functional role remains debated.

Population

Patients suffering Chronic Lymphocytic Leukemia (CLL)

Design

Review

Authors

DPDaniel PrietoPOPablo Oppezzo

Discussion

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Overview

Supports LPL as CLL prognostic marker; leaves open its metabolic role and therapeutic potential.

Structured PICO

P
Population
Patients suffering Chronic Lymphocytic Leukemia (CLL)

This review highlights the role of lipoprotein lipase as a prognostic marker in chronic lymphocytic leukemia and discusses its potential metabolic functions in tumor cells.

Cite This Study

Prieto et al. (2017) conducted a review in Chronic Lymphocytic Leukemia. Lipoprotein lipase (LPL) expression was evaluated. Lipoprotein lipase expression in tumor cells is linked to poor clinical outcomes in patients with chronic lymphocytic leukemia, though its functional role remains debated.

synapsesocial.com/papers/6a64b58707dad03009ef3ff1https://doi.org/10.3390/molecules22122083
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aberrant LPL Expression, Driven by STAT3, Mediates Free Fatty Acid Metabolism in CLL Cells2015 · 89 citations
  2. 2Lipoprotein Lipase Links Dietary Fat to Solid Tumor Cell Proliferation2011 · 289 citations
  3. 3A link between hypercholesterolemia and chronic lymphocytic leukemia2015 · 34 citations
  4. 4New wrinkles in lipoprotein lipase biology2011 · 59 citations
  5. 5Abolishment of Alimentary Lipemia Following Injection of Heparin1943 · 607 citations