Four weeks of intense handgrip training increased exercise forearm vascular conductance (0.2534 vs 0.1330 units; P<0.05) but did not affect the vascular response to endothelium-dependent vasodilators.
Does intense handgrip exercise training affect endothelium-dependent exercise-induced vasodilatation in human subjects?
Intense handgrip exercise training increases exercise forearm vascular conductance but does not alter the specific vascular response to endothelium-dependent or independent vasodilators.
Absolute Event Rate: 0.2534% vs 0.133%
p-value: p=< 0.05
To determine whether intense exercise training affects exercise-induced vasodilatation, six subjects underwent 4 weeks of handgrip training at 70% of maximal voluntary contraction. Exercise forearm vascular conductance (FVC) responses to an endothelium-dependent vasodilator (acetylcholine, ACH; 15, 30, 60 micrograms min-1) and an endothelium-independent vasodilator (sodium nitroprusside, SNP; 1.6, 3.2, 6.4 micrograms min-1) and FVC after 10 min of forearm ischaemia were determined before and after training. Training elicited significant (P 0.4), but exercise FVC increased (0.1330 +/- 0.0190 vs. 0.2534 +/- 0.0387 units, P 0.6). These results suggest that exercise FVC is increased by both exercise training and stimulating the release of endothelium-dependent vasodilators. However, training does not affect the vascular response to these vasodilators.
Franke et al. (Sun,) reported a other. Intense exercise training (handgrip training) vs. Before training (baseline) was evaluated on Exercise forearm vascular conductance (FVC) (p=< 0.05). Four weeks of intense handgrip training increased exercise forearm vascular conductance (0.2534 vs 0.1330 units; P<0.05) but did not affect the vascular response to endothelium-dependent vasodilators.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: