Key result
Hemodialysis sessions were associated with lower mean glucose values (7.5 vs. 9.4 mmol/l; p<0.001) and a higher frequency of hypoglycemia (4.4% vs. 2.1%; p<0.001) in diabetic patients.
Why the study?
Does hemodialysis affect the glucose profile in diabetic patients on insulin as measured by continuous glucose monitoring?
Observational (n=33)
Does hemodialysis affect the glucose profile in diabetic patients on insulin as measured by continuous glucose monitoring?
Absolute Event Rate: 7.5% vs 9.4%
p-value: p=<0.001
Continuous glucose monitoring reveals that hemodialysis sessions are associated with lower mean glucose levels and a higher risk of hypoglycemia in diabetic patients on insulin.
May warrant closer intradialytic glucose monitoring in insulin-treated diabetes; leaves open whether this association is causal or modifiable.
We sought to investigate the impact of dialysis on glucose profiles of diabetic patients using continuous glucose monitoring (CGM). The study included 33 hemodialyzed patients with diabetes (14 females and 19 males; mean age: 66±8 years; patients with type 2 diabetes: 30; mean duration of dialysis: 3.8±2.6 years) who were under insulin treatment. After a run-in period, CGM was performed for 48 h, including a dialysis session. Three CGM sessions were proposed for each patient over a 3-month period. CGM results were analyzed during and after dialysis at 6 different time points. Moreover, data were analyzed in 7 different day periods according to meals. Of the 99 CGM available, 21 were excluded because of technical issues or patient refusal. The CGM results indicated that mean glucose values (7.5±2.5 mmol/l vs. 9.4±1.9 mmol/l; p<0.001) and variability indices (p<0.001) were lower, whereas the frequency of hypoglycemia (4.4±9.6% vs. 2.1±7.9%; p<0.001) was higher during hemodialysis sessions. Significant differences were observed in glucose values only before and 2 h after breakfast (p<0.001). Compared with other day periods, glucose values were lower during the second half of the night and higher before and after dinner (p<0.001). In summary, CGM allows the identification of a particular glucose profile in hemodialyzed diabetic patients. CGM seems feasible and clinically useful for the analysis of glucose profiles in this group of patients.
No takes yet. Share an insight, caveat, or question.
Chantrel et al. (2014) conducted an observational in Diabetes in hemodialyzed patients (n=33). Hemodialysis session vs. Non-dialysis periods was evaluated on Mean glucose values (p=<0.001). Hemodialysis sessions were associated with lower mean glucose values (7.5 vs. 9.4 mmol/l; p<0.001) and a higher frequency of hypoglycemia (4.4% vs. 2.1%; p<0.001) in diabetic patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: