What question did this study set out to answer?

The aim is to investigate the presence of RHD pseudogene mutations in Rh D-negative Africans and their implications for blood typing.

January 1, 2000Blood

The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype

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Randomized trial identifies RHD pseudogene mutations in Africans with Rh D-negative blood, suggesting new testing methods.

The aim is to investigate the presence of RHD pseudogene mutations in Rh D-negative Africans and their implications for blood typing.
Identified RHDpsi through genetic analysis in a sample of 82 D-negative black Africans.
Compared frequencies of RHDpsi and other genetic variants among African and African American subjects.
Developed a PCR test to detect the 37 bp insert in RHDpsi for improved blood phenotype prediction.
66% of D-negative black Africans had the RHDpsi mutation, while 15% had the hybrid gene.
RHDpsi frequency is about 0.0714 in black South Africans and 24% in D-negative African Americans.
Existing PCR tests were unsuitable for populations with high proportions of RHDpsi.

Singleton et al. (2000) studied this question.

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