Key result
Furosemide plus losartan inhibited the 0.03-0.05 Hz tubuloglomerular feedback mechanism, while the 0.1-0.2 Hz mechanism remained unaltered and attenuated ~50% of blood pressure fluctuations.
Population
Normotensive and hypertensive rats under isoflurane or halothane anesthesia
Comparison
Furosemide plus the angiotensin II AT1 receptor… vs Control
Design
Preclinical
Authors
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Myogenic mechanism attenuates ~50% of BP fluctuations independently in rats; leaves open its isolated contribution in human renal disease.
The faster myogenic mechanism of renal autoregulation (0.1-0.2 Hz) can independently stabilize renal blood flow against spontaneous blood pressure fluctuations even when tubuloglomerular feedback is pharmacologically blocked.
Ajikobi et al. (1996) studied Normotension and hypertension (animal model). Furosemide plus losartan vs. Control (baseline) was evaluated on Renal blood flow dynamics (0.1-0.2 Hz and 0.03-0.05 Hz mechanisms). Furosemide plus losartan inhibited the 0.03-0.05 Hz tubuloglomerular feedback mechanism, while the 0.1-0.2 Hz mechanism remained unaltered and attenuated ~50% of blood pressure fluctuations.
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