Key result
Apelin-13 treatment significantly improved blood pressure, proteinuria, renal function markers, and kidney histoarchitecture in L-NAME-induced preeclamptic rats.
Why the study?
Pre-eclampsia remains a major cause of maternal and fetal morbidity, involving oxidative stress, inflammation, and reduced apelin levels, motivating evaluation of apelin-13 on associated renal dysfunction.
Does apelin-13 improve renal dysfunction and proteinuria in L-NAME-induced preeclamptic rats?
Does apelin-13 improve renal dysfunction and proteinuria in L-NAME-induced preeclamptic rats?
Apelin-13 administration ameliorates hypertension, renal dysfunction, and oxidative stress in a rat model of L-NAME-induced preeclampsia.
Answers are grounded in this paper and cite their sources.
Apelin-13 improves renal markers in rat preeclampsia models; hypothesis-generating and should not change clinical practice.
Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria. Thirty-three pregnant female rats were divided into three groups; group: 1 (normal pregnant rats), group: 2 (preeclamptic rats); where rats were injected subcutaneously with 75 mg L-NAME/ kg body weight/day beginning from 9th to 20th day of pregnancy andgroup 3 (apelin-13 treated preeclamptic rats); In which L-NAME-induced preeclamptic rats were subcutaneously injected with 6 × 10 −8 mol apelin-13/kg body weight/twice daily starting from 6th to 20th day of pregnancy. In all groups, mean arterial blood pressure, total urine protein, serum urea, creatinine, nitric oxide (NO), endothelin-1 (ET-1), interleukin–6 (IL-6) and malondialdhyde (MDA) were measured. Histopathological examination of kidney tissues was also done. preeclamptic rats showed significantly increased mean arterial blood pressure, total urine proteins, serum urea, creatinine, ET-1, IL-6, and MDA, but revealed a significantly decreased serum NO level. On the other hand, apelin treatment significantly improved these parameters together with amelioration of kidney histoarchitecture in the treated group. In conclusion, apelin may be a potentially curative candidate for prohibiting kidney damage and have a therapeutic benefit in PE rat models.
No takes yet. Share an insight, caveat, or question.
Hamza et al. (2021) studied L-NAME-induced preeclampsia (n=33). Apelin-13 vs. Untreated L-NAME-induced preeclamptic rats was evaluated on Mean arterial blood pressure, total urine protein, serum urea, creatinine, NO, ET-1, IL-6, MDA, and kidney histopathology. Apelin-13 treatment significantly improved blood pressure, proteinuria, renal function markers, and kidney histoarchitecture in L-NAME-induced preeclamptic rats.
Synapse has enriched 10 related papers. Consider them for comparative context: