Key result
In 359 hypertensive patients, type 2 diabetes was associated with significantly higher levels of platelet-, monocyte-, and endothelial cell-derived microparticles compared to non-diabetic patients.
Cross-Sectional (n=359)
The presence of diabetes in hypertensive patients enhances the generation of platelet-derived microparticles and their association with monocyte- and endothelial-derived microparticles, potentially contributing to atherothrombotic complications.
Does not support clinical microparticle profiling in hypertensive diabetes; leaves open their prognostic or therapeutic relevance.
Elevated platelet-derived mircoparticles (MP) (PDMP), endothelial cell-derived MP (EDMP), and monocyte-derived MP (MDMP) concentrations are documented in almost all thrombotic diseases. However, the intricate interactions between PDMP, MDMP and EDMP in hypertensive patients with or without type 2 diabetes remains poorly understood. Therefore, to clarify the correlation and association of MPs, we measured and analysed the levels of MPs in 359 hypertensive patients. We compared the results of chemokines, cell adhesion molecules, platelet activation markers and microparticles in hypertensive patients with and without type 2 diabetes mellitus. The levels of all markers were significantly higher in the hypertensive patients with diabetes than in the non-diabetic patients. For hypertensive patients with diabetes, univariate analysis showed that age, body mass index, systolic blood pressure, high density lipoprotein cholesterol (HDL-CHO), creatinine (CRTN), soluble P-selectin (sP-selectin), soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble CD40 ligand (sCD40L), regulated on activation normally T-cell expressed and secreted (RANTES), monocyte chemotactic peptide-1 (MCP-1), MDMP and EDMP were significantly associated with PDMP. In addition, systolic blood pressure, HDL cholesterol, sP-selectin, sE-selectin, sVCAM-1, sCD40L, RANTES, MDMP and EDMP were significant factors in the multivariate model with PDMP. Furthermore, a correlation between plasma PDMP and MDMP or EDMP in hypertensive patients were observed both with and without diabetes. These results suggest that the existence of diabetes mellitus affects PDMP generation in hypertensive patients and that enhanced plasma levels of PDMP and an association between the plasma levels of PDMP, MDMP and EDMP may result in the development of atherothrombotic complications in hypertensive patients.
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Nomura et al. (2009) conducted a cross-sectional in Hypertension with or without type 2 diabetes mellitus (n=359). Type 2 diabetes mellitus vs. Without type 2 diabetes mellitus was evaluated on Levels of chemokines, cell adhesion molecules, platelet activation markers and microparticles. In 359 hypertensive patients, type 2 diabetes was associated with significantly higher levels of platelet-, monocyte-, and endothelial cell-derived microparticles compared to non-diabetic patients.
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