Key result
In patients undergoing cardiac resynchronization therapy, there was a strong correlation between electrical and mechanical delay times (R2 = 0.78 ± 0.23), with the latest electrically activated location matching the latest mechanically contracting location in 91% of patients.
Why the study?
Does non-invasive mechanical activation measured by CMR correlate with intra-operative electrical delay times in patients undergoing CRT?
Observational (n=11)
No
Does non-invasive mechanical activation measured by CMR correlate with intra-operative electrical delay times in patients undergoing CRT?
Non-invasive mechanical activation patterns obtained via CMR accurately reflect the underlying electromechanical substrate of intraventricular dyssynchrony, potentially aiding in optimal LV lead placement in CRT.
BACKGROUND: It is important to understand the relationship between electrical and mechanical ventricular activation in CRT patients. By measuring local electrical activation at multiple locations within the coronary veins and myocardial contraction at the same locations in the left ventricle, we determined the relationship between electrical and mechanical activation at potential left ventricular pacing locations. METHODS: In this study, mechanical contraction times were computed using high temporal resolution cine cardiovascular magnetic resonance (CMR) data, while electrical activation times were derived from intra-procedural local electrograms. RESULTS: In our cohort, there was a strong correlation between electrical and mechanical delay times within each patient (R2=0.78 ± 0.23). Additionally, the latest electrically activated location corresponded with the latest mechanically contracting location in 91% of patients. CONCLUSIONS: This study provides initial evidence that our method of obtaining non-invasive mechanical activation patterns accurately reflects the underlying electromechanical substrate of intraventricular dyssynchrony.
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Suever et al. (2014) conducted an observational in Heart failure (n=11). Intra-operative electrical delay times and mechanical dyssynchrony was evaluated on Correlation between electrical and mechanical delay times within each patient (R2 = 0.78 ± 0.23). In patients undergoing cardiac resynchronization therapy, there was a strong correlation between electrical and mechanical delay times (R2 = 0.78 ± 0.23), with the latest electrically activated location matching the latest mechanically contracting location in 91% of patients.
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