Key result
Introducing motion into the cardiac model modifies the ECG signals compared to static simulation, with the most obvious change occurring during the T-wave at peak contraction of the ventricles.
Incorporating cardiac motion into computational electrical models alters simulated ECG signals and body surface potential maps, particularly during the T-wave, which may improve the accuracy of inverse cardiac models.
Enables realistic simulation of ventricular electrophysiology with MRI-derived motion; leaves open clinical validation and application in ECG interpretation.
This paper describes an electrical model of cardiac ventricles incorporating real geometry and motion. The heart anatomy and its motion through the cardiac cycle are obtained from segmentations of multiple-slice MRI time sequences; the special conduction system is constructed using an automated mapping procedure from an existing static heart model. The heart model is mounted in an anatomically realistic voxel model of the human body. The cardiac electrical source and surface potentials are determined numerically using both a finite-difference scheme and a boundary-element method with the incorporation of the motion of the heart. The electrocardiograms (ECG) and body surface potential maps are calculated and compared to the static simulation in the resting heart. The simulations demonstrate that introducing motion into the cardiac model modifies the ECG signals, with the most obvious change occurring during the T-wave at peak contraction of the ventricles. Body surface potential maps differ in some local positions during the T-wave, which may be of importance to a number of cardiac models, including those incorporating inverse methods.
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Wei et al. (2006) studied this question. Introducing motion into the cardiac model vs. Static simulation in the resting heart was evaluated on Electrocardiograms (ECG) and body surface potential maps. Introducing motion into the cardiac model modifies the ECG signals compared to static simulation, with the most obvious change occurring during the T-wave at peak contraction of the ventricles.
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