Review discusses RET-mediated signaling mechanisms in tumors and developmental disorders, highlighting functional insights.
The rearranged during transfection (RET) receptor tyrosine kinase is physiologically stimulated by growth factors belonging to the glial cell line-derived neurotrophic factor family and by the growth differentiation factor-15 cytokine. RET plays a critical role in normal development as well as in various human tumors and developmental disorders. This review focuses on mechanisms of RET signaling and their alterations in human diseases.
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Carlomagno et al. (2024) studied this question.
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