Synergic Trio of Metabolic Regulators Supporting the Vicious Circle of Pathological Processes in Post-Traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a maladaptive response to exposure of extreme intensity stressor. The body of animals and humans reacts at the systemic and cellular levels, as with any response to external challenges. Disorder of the collective work of stress-realizing and stress-limiting systems causes transformation of behavior, cognitive abilities and other functions of the central nervous system in stress-sensitive individuals. Currently, it has been proven that in the pathogenesis of PTSD, an important place is occupied by changes in the number and composition of the intestinal microbiota. In this regard, methods of improving the microflora are being considered. Analyzing data of Russian and foreign researchers, the authors came to the conclusion, that metabolic, somatic and mental health largely depends on the coordinated functioning of the main interdependent components of metabolism: hepatobiliary system, intestinal microbiota and, according to the authors, on the state of mast cells. A close study of the interaction of these components will allow us to identify new therapeutic targets and the most effective methods of treating PTSD.