April 1, 2001Anesthesia & Analgesia
Apolipoprotein E Polymorphisms and Age at First Coronary Artery Bypass Graft
Key result
The presence of one or more copies of the apoE4 allele was associated with an earlier age at first coronary artery bypass graft compared to patients without the allele (P=0.032).
Why the study?
Does the presence of the apoE4 allele correlate with an earlier age at first CABG in patients undergoing primary CABG?
Population
560 patients undergoing primary CABG
Comparison
Presence of one or more copies of the apoE4 allele vs Absence of the apoE4 allele
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
ApoE4 may link to earlier CABG; leaves open its value for CAD risk stratification pending validation.
Study Design
Type
Observational (n=560)
Structured PICO
Does the presence of the apoE4 allele correlate with an earlier age at first CABG in patients undergoing primary CABG?
P
Population
560 patients undergoing primary coronary artery bypass graft (CABG) assessed for the impact of apoE4 genotype on age at presentation.
E
Exposure
Presence of one or more copies of the apoE4 allele
C
Comparator
Absence of the apoE4 allele
O
Outcome
Age at first CABG
Main Result
p-value: p=0.032
The apoE4 allele is associated with an earlier age of presentation for primary CABG, suggesting a genetic predisposition to accelerated coronary artery disease.
Limitations
- Small number of patients in individual genotype groups
Cite This Study
Newman et al. (2001) conducted an observational in Coronary artery disease (n=560). apoE4 allele vs. No copies of the apoE4 allele was evaluated on Age at first CABG (p=0.032). The presence of one or more copies of the apoE4 allele was associated with an earlier age at first coronary artery bypass graft compared to patients without the allele (P=0.032).