What is the clinical evidence from this study?

Study design: Other. Population: Left ventricular hypertrophy (n=36). Intervention: Aortic stenosis vs. Sham-operated controls. Primary outcome: Myocardial performance and relaxation.

What question did this study set out to answer?

The aim is to investigate alterations in relaxation dynamics during cardiac hypertrophy induced by aortic stenosis in guinea pigs.

July 1, 1987Circulation Research

Major alterations in relaxation during cardiac hypertrophy induced by aortic stenosis in guinea pig.

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Key result

Severe cardiac hypertrophy induced by aortic stenosis in guinea pigs markedly decreased myocardial performance and impaired relaxation compared to sham-operated controls.

Population

Guinea pigs with left ventricular hypertrophy induced by aortic stenosis.

Comparison

Aortic stenosis inducing cardiac overload for 3… vs Sham-operated controls.

Design

Preclinical

Follow-up

3 weeks

Authors

YLYves LecarpentierUniversité Claude Bernard Lyon 1 AWAnders WaldenströmHeart Failure & Transplant MCMichel ClergueInserm

Discussion

Member takes

Implication

May guide preclinical LVH models; leaves open translation to human pressure-overload disease.

Key Points

The aim is to investigate alterations in relaxation dynamics during cardiac hypertrophy induced by aortic stenosis in guinea pigs.
Induced left ventricular hypertrophy in guinea pigs after aortic stenosis.
Conducted mechanical studies on excised LV papillary muscles from animals with mild and severe hypertrophy.
Measured parameters including isometric relaxation and contractility across different severity levels.
Mild hypertrophy showed no significant differences compared to controls, while severe hypertrophy revealed a marked decrease in myocardial performance (Vmax, 22%; active force, 23%).
Relaxation was more impaired than contraction, with peak lengthening velocity at 14% and -dF/dt max at 19%.
Isometric relaxation delay increased by 15% in severe hypertrophy, indicating significant functional alterations.

Structured PICO

Population

36 guinea pigs with left ventricular hypertrophy induced by aortic stenosis or sham operation, evaluated after 3 weeks of cardiac overload.

Intervention

Aortic stenosis inducing cardiac overload for 3 weeks, and acute hypoxia (95% N2-5% CO2 for 20 minutes).

Comparator

Sham-operated controls.

Outcome

Myocardial performance and relaxation parameters of excised LV papillary muscles (Vmax, active isometric force, +dF/dt max, peak lengthening velocity, -dF/dt max, load sensitivity, t 1/2).surrogate

Severe cardiac hypertrophy induced by pressure overload in guinea pigs causes profound impairment in myocardial relaxation and loss of load sensitivity, suggesting alterations in the sarcoplasmic reticulum.

Cite This Study

Lecarpentier et al. (1987) studied Left ventricular hypertrophy (n=36). Aortic stenosis vs. Sham-operated controls was evaluated on Myocardial performance and relaxation. Severe cardiac hypertrophy induced by aortic stenosis in guinea pigs markedly decreased myocardial performance and impaired relaxation compared to sham-operated controls.

synapsesocial.com/papers/6a64e4bf5dee09b701c6c1bc https://doi.org/10.1161/01.res.61.1.107

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Major alterations in relaxation during cardiac hypertrophy induced by aortic stenosis in guinea pig.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Major alterations in relaxation during cardiac hypertrophy induced by aortic stenosis in guinea pig.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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