Key result
Young survivors of myocardial infarction demonstrated reduced platelet sensitivity to prostacyclin and higher plasma fibrinogen levels compared to healthy matched controls.
Why the study?
Do young survivors of myocardial infarction have altered platelet function and plasma fibrinogen levels compared to healthy matched controls?
Case-Control (n=146)
Do young survivors of myocardial infarction have altered platelet function and plasma fibrinogen levels compared to healthy matched controls?
Young survivors of myocardial infarction exhibit reduced platelet sensitivity to prostacyclin and elevated fibrinogen levels, suggesting an increased thrombotic liability.
May indicate need for tailored antithrombotic strategies in young MI patients; extends evidence on persistent platelet abnormalities post-event.
Seventy-three (58 men and 15 women) survivors of myocardial infarction below 45 years of age and 73 healthy matched controls were investigated regarding in vitro platelet aggregability to ADP and collagen, platelet sensitivity to prostacyclin and plasma levels of beta-thromboglobulin, platelet factor 4 and fibrinogen. The patients, studied 3-6 months after the acute event, had a reduced platelet sensitivity to prostacyclin. They did not differ from the controls regarding the other platelet function tests. Females had higher platelet reactivity than men. Smoking, obesity or beta-blocker treatment did not influence platelet function. The patients had higher fibrinogen levels than the controls. Gender did not influence, while smoking and obesity increased plasma fibrinogen. Patients on beta-blockade had lower fibrinogen levels than patients without this therapy. The high fibrinogen level and the low platelet sensitivity to prostacyclin might indicate an increased thrombotic liability in young myocardial infarction patients.
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Berglund et al. (1988) conducted a case-control in Myocardial infarction (n=146). Prior myocardial infarction vs. Healthy matched controls was evaluated on Platelet sensitivity to prostacyclin and plasma fibrinogen levels. Young survivors of myocardial infarction demonstrated reduced platelet sensitivity to prostacyclin and higher plasma fibrinogen levels compared to healthy matched controls.
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