January 1, 1987Thrombosis and Haemostasis
Platelet Reactivity in Unstable Coronary Artery Disease
Key result
Acute unstable CAD is linked to transiently reduced platelet sensitivity to prostacyclin.
- n=164
Why the study?
Unstable coronary artery disease may be related to coronary blood flow obstructions by platelet aggregates, but platelet reactivity characteristics in this condition are not fully understood.
Comparison
Patients with unstable CAD vs patients without signs of ischemia
Design
Observational study measuring platelet function and plasma markers
Follow-up
12 months
Authors
Discussion
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Implication
Transient prostacyclin resistance may heighten acute thrombotic risk in unstable CAD; hypothesis-generating and requires prospective validation.
Study Design
Type
Observational (n=164)
PICO
P
Population
164 patients admitted with suspected unstable CAD, grouped by the development of myocardial ischemia or infarction, and followed for 12 months.
E
Exposure / Comparator
Unstable CAD (presence of nontransmural myocardial infarction or ischemia) vs Patients without signs of ischemia
O
Primary Outcome
Platelet sensitivity to prostacyclin (PSP) and aggregability towards ADP
Cite This Study
Swahn et al. (1987) conducted an observational in Suspected unstable coronary artery disease (CAD) (n=164). Unstable CAD (presence of nontransmural myocardial infarction or ischemia) vs. Patients without signs of ischemia was evaluated on Platelet sensitivity to prostacyclin (PSP) and aggregability towards ADP. Patients with unstable CAD had reduced platelet sensitivity to the inhibitory effects of prostacyclin in the acute phase compared to controls, with no differences observed after 12 months.