Why the study?
Does residual platelet reactivity predict the severity of myocardial infarction (measured by cardiac necrosis markers) in patients with MI after PCI on antiplatelet therapy?
Population
367 patients with myocardial infarction after percutaneous coronary intervention, including 200 on dual…
Comparison
Residual platelet reactivity measured by PFA-100… vs Absence of residual platelet reactivity or lower…
Design
Cohort
Authors
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Residual platelet reactivity may signal greater post-PCI necrosis; hypothesis-generating and requires prospective confirmation before practice change.
Does residual platelet reactivity predict the severity of myocardial infarction (measured by cardiac necrosis markers) in patients with MI after PCI on antiplatelet therapy?
Persistent platelet activation despite multiple antiplatelet therapies independently predicts larger myocardial infarction size, as measured by cardiac necrosis markers, in patients undergoing primary PCI.
Paniccia et al. (2007) studied this question.
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