Key result
In healthy young men, 131I-labeled antithrombin III distributed into plasma (39.3%), noncirculating vascular-associated (10.9%), and extravascular (49.6%) pools.
Population
5 healthy young men
Design
Other
Authors
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AT three-pool distribution in humans cautions against plasma-only monitoring; leaves open validation for dosing in deficiency states.
Observational (n=5)
In humans, antithrombin III distributes among plasma, noncirculating vascular-associated, and extravascular pools, supporting a model where vascular AT interacts with an endothelial receptor.
Carlson et al. (1985) conducted an observational in Healthy (n=5). 131I-labeled antithrombin III was evaluated on Fractions of total-body antithrombin III in the plasma, noncirculating vascular-associated, and extravascular pools. In healthy young men, 131I-labeled antithrombin III distributed into plasma (39.3%), noncirculating vascular-associated (10.9%), and extravascular (49.6%) pools.
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