Population
Segments from freshly excised rabbit thoracic aorta (normal and deendothelialized)
Design
Preclinical
Authors
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Hypothesis-generating for antithrombin III inactivation of arterial thrombin; leaves open human relevance and clinical translation.
The study demonstrates that thrombin bound to high-affinity sites on the endothelium is inactivated by plasma antithrombin III, supporting its role in large arteries.
Hatton et al. (1986) studied this question.
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