Why the study?
Does antithrombin III increase the capacity to inactivate thrombin on rabbit aortae endothelium in vitro?
Population
Rabbit aortae in vitro
Comparison
Incubation with antithrombin III (ATIII) vs Incubation with heparin alone, or prior…
Design
Preclinical
Authors
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Vessel wall ATIII may determine endothelial thrombin inhibition; leaves open clinical translation in humans.
Does antithrombin III increase the capacity to inactivate thrombin on rabbit aortae endothelium in vitro?
The study demonstrates that vessel wall antithrombin III content is a key determinant for thrombin inhibition capacity and is likely bound to glycosaminoglycans.
Frebelius et al. (1990) studied this question.
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