Why the study?
Does treatment with antithrombin III or heparin reduce thrombin coagulant activity on the injured vessel wall in a rabbit balloon injury model?
Population
Rabbit aorta model after in vivo balloon injury
Comparison
Continuous treatment with heparin or treatment… vs Heparin given only in conjunction with the injury
Design
Preclinical
Authors
Loading...
Hypothesis-generating for antithrombin III or continuous heparin after vascular injury; leaves open translation to human thrombosis prevention.
Does treatment with antithrombin III or heparin reduce thrombin coagulant activity on the injured vessel wall in a rabbit balloon injury model?
Treatment with antithrombin III interferes with thrombin appearance on the vessel wall after balloon injury, potentially reducing the risk for thrombosis.
Frebelius et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: