April 23, 2008European Surgical Research

Inhibition of Thrombin on Subendothelium

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Why the study?

Does antithrombin III decrease thrombin enzymatic activity on injured rabbit aorta compared to heparin?

Population

Rabbit aorta after superficial and deep injury to the vessel wall

Design

Preclinical

Authors

SNS. NydahlKarolinska University Hospital SFSiw FrebeliusKarolinska Institutet JSJesper SwedenborgKarolinska University Hospital

Discussion

Member takes

Implication

ATIII may attenuate thrombin activity after arterial injury in models; leaves open any clinical advantage over heparin pending human data.

Structured PICO

Does antithrombin III decrease thrombin enzymatic activity on injured rabbit aorta compared to heparin?

Population

Rabbit aorta after superficial and deep injury to the vessel wall

Intervention

Exposure to antithrombin III (AT) or heparin

Outcome

Thrombin enzymatic activity on the subendotheliumsurrogate

In a rabbit aorta injury model, antithrombin III decreased thrombin activity on injured vessels, suggesting it may be preferable to heparin for arterial injury.

Cite This Study

Nydahl et al. (2008) studied this question.

synapsesocial.com/papers/6a8a5e5d5c4c6b099dec9237 https://doi.org/10.1159/000129039

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Ask AI

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Implication

ATIII may attenuate thrombin activity after arterial injury in models; leaves open any clinical advantage over heparin pending human data.

Inhibition of Thrombin on Subendothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of Thrombin on Subendothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider