January 1, 1994Journal of Vascular Research
Thrombin Generation following Arterial Injury Is a Critical Initiating Event in the Pathogenesis of the Proliferative Stages of the Atherosclerotic Process
Why the study?
Does administration of thrombin antagonists reduce neointimal hyperplasia following balloon catheter aortic injury in rabbits?
Population
Rabbits subjected to balloon catheter aortic injury (n=16) and control rabbits with intact endothelium (n=8)
Comparison
Thrombin antagonists (r-hirudin and P-PACK) vs Untreated rabbits with balloon catheter aortic…
Design
Preclinical
Follow-up
3 weeks
Authors
Discussion
Loading...
Member takes
Implication
Thrombin antagonists may limit restenosis after vascular injury; hypothesis-generating for human trials.
Structured PICO
Does administration of thrombin antagonists reduce neointimal hyperplasia following balloon catheter aortic injury in rabbits?
P
Population
Rabbits subjected to balloon catheter aortic injury (n=16) and control rabbits with intact endothelium (n=8)
I
Intervention
Thrombin antagonists (r-hirudin and P-PACK)
C
Comparator
Untreated rabbits with balloon catheter aortic injury, and rabbits with intact endothelium
O
Outcome
Neointimal hyperplasia as measured by the intimal/medial ratio at 3 weekssurrogate
Thrombin antagonists significantly inhibit neointimal hyperplasia and lipid peroxidation following arterial injury in a rabbit model, suggesting thrombin plays a critical role in restenosis.
Cite This Study
Walters et al. (1994) studied this question.