Key result
Thrombin treatment of the endothelium does not cause platelets to adhere, but increases platelet accumulation on areas where the subendothelium is exposed or endothelial cells are damaged.
Population
Rabbit aortae removed from exsanguinated rabbits
Comparison
Thrombin treatment, with or without subsequent… vs Normal rabbit aortae
Design
Preclinical
Authors
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Thrombin-driven platelet accumulation at damaged endothelium may favor heparin over aspirin in animal models; leaves open clinical translation for targeted antithrombotics.
Thrombin promotes platelet accumulation specifically at sites of endothelial damage, an effect that can be reversed by heparin but is unaffected by aspirin.
Dejan et al. (1983) studied Platelet accumulation on vessel wall. Thrombin pretreatment vs. Normal rabbit aortae (untreated) was evaluated on Platelet accumulation on the vessel wall. Thrombin treatment of the endothelium does not cause platelets to adhere, but increases platelet accumulation on areas where the subendothelium is exposed or endothelial cells are damaged.
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