Why the study?
Does pharmacological modulation with antithrombin or fibrinolytic agents reduce thrombin-induced intracranial platelet and fibrinogen accumulation in a rabbit model?
Population
Anaesthetized rabbits with intracarotid thrombin-induced cerebral thromboembolism
Design
Preclinical
Authors
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Findings remain preclinical and should not guide patient care; leaves open translation of antithrombin and fibrinolytic effects to human cerebrovascular disease.
Does pharmacological modulation with antithrombin or fibrinolytic agents reduce thrombin-induced intracranial platelet and fibrinogen accumulation in a rabbit model?
Fibrin deposition plays a critical role in thrombin-induced cerebral thromboembolism in rabbits, as evidenced by the efficacy of antithrombin and fibrinolytic agents in reversing platelet and fibrinogen accumulation.
May et al. (1992) studied this question.
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