Key result
Heparin accelerated the binding and increased the utilization of the binding capacity of antithrombin III in thrombin-involving reactions, while heparin itself was neutralized by the complex.
Authors
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In vitro heparin-antithrombin dynamics are hypothesis-generating; clinical relevance requires in vivo validation before practice consideration.
Ewa Marciniak (1977) studied this question. Heparin vs. Thrombin alone was evaluated on Inhibitory capacity of antithrombin III and neutralization of heparin. Heparin accelerated the binding and increased the utilization of the binding capacity of antithrombin III in thrombin-involving reactions, while heparin itself was neutralized by the complex.
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