Population
In vitro prothrombin activation mixtures containing prothrombin, factor Xa, factor Va, and phospholipid
Comparison
Antithrombin III and heparin vs Absence of factor Va and phospholipid
Design
Preclinical
Authors
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Prothrombinase-bound Xa may resist ATIII inhibition; leaves open heparin's efficacy in active coagulation states.
Factor Xa acting in the prothrombinase complex is profoundly protected from inhibition by antithrombin III, both in the presence and absence of heparin.
Lindhout et al. (1986) studied this question.
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