Population
Plasma samples and literature data on antithrombin and heparin characteristics
Comparison
Addition of heparin or saline dilution to plasma vs Isolated heparin cofactor preparation or normal…
Design
Preclinical
Authors
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Explains heparin action via antithrombin kinetics alone in plasma; leaves open independent cofactors in human or diseased states.
The action of heparin in plasma can be quantitatively accounted for by its effects on antithrombin, suggesting an independent heparin cofactor does not exist in normal plasma.
Waugh et al. (1956) studied this question.
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