What question did this study set out to answer?

This study aims to understand the kinetics of heparin's anticoagulant effect using various assay methods.

June 1, 1970JAMA

Kinetics of the Anticoagulant Effect of Heparin

View Full Paper

Ask AI

Bookmark

Population

Human subjects

Design

Other

Authors

JEJ. Worth EstesUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

May inform weight-based heparin dosing and assay selection now; leaves open optimal monitoring strategies pending modern outcome trials.

Key Points

This study aims to understand the kinetics of heparin's anticoagulant effect using various assay methods.
Evaluated four assay methods for measuring heparin's anticoagulant activity in human subjects.
Administered single intravenous doses of heparin within the clinical dose range.
Measured the anticoagulant half-life and minimum effective doses.
The half-life of heparin's anticoagulant activity is approximately 1.5 hours.
Minimum effective dose required is about 35 units/kg to achieve desirable anticoagulation.
The whole-blood activated partial thromboplastin time assay demonstrated the highest precision and efficiency.

Structured PICO

Population

Human subjects

Intervention

Heparin (single intravenous doses within the usual clinical dose range)

Outcome

Kinetics of anticoagulant activity (including half-life and minimum dose required)surrogate

The half-life of intravenous heparin is approximately 1.5 hours, with the whole-blood activated partial thromboplastin time identified as the most precise and economical assay for monitoring its effect.

Cite This Study

J. Worth Estes (1970) studied this question.

synapsesocial.com/papers/6a6fe012f44fa9f079dd5e38 https://doi.org/10.1001/jama.1970.03170220048007

View Full Paper

Ask AI

Bookmark

Kinetics of the Anticoagulant Effect of Heparin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Kinetics of the Anticoagulant Effect of Heparin

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider