What question did this study set out to answer?

This research aims to study how different heparin brands behave in the body after administration.

December 1, 1982BloodOpen Access

Kinetics of intravenously administered heparin in normal humans

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Why the study?

What are the clearance kinetics of intravenously administered heparin in normal humans?

Population

Normal humans and patients treated for deep vein thrombosis or pulmonary embolism

Design

Other

Authors

CSCA de SwartCalifornia State University System BNB NijmeyerCalifornia State University System JRJM RoelofsUtrecht University

Discussion

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Implication

May inform heparin assay choice during infusion; extends saturable-linear clearance model but leaves dosing validation open.

Key Points

This research aims to study how different heparin brands behave in the body after administration.
Intravenous heparin was administered via bolus injection and continuous infusion.
Anticoagulant activity was measured using two assays: APTT and anti-Xa activity.
Data analysis revealed a non-linear disappearance of heparin activity.
APTT activity decreased faster than anti-Xa activity post-bolus injection.
Higher anticoagulant levels were observed with the anti-Xa assay during continuous infusion.
A model for heparin clearance included both saturable and linear mechanisms.

Structured PICO

What are the clearance kinetics of intravenously administered heparin in normal humans?

Population

Normal humans and patients treated for deep vein thrombosis or pulmonary embolism

Intervention

Intravenously administered heparin (bolus injection and continuous infusion, 5 commercially available brands)

Outcome

Disappearance of heparin anticoagulant activity (clearance kinetics)surrogate

The clearance of intravenous heparin involves both saturable and linear mechanisms, providing a pharmacokinetic model to guide dose adjustments in individual patients.

Cite This Study

Swart et al. (1982) studied this question.

synapsesocial.com/papers/6a728e6dfebe604dd70aaa8e https://doi.org/10.1182/blood.v60.6.1251.1251

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Kinetics of intravenously administered heparin in normal humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Kinetics of intravenously administered heparin in normal humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider