Why the study?
Does activated partial thromboplastin time correlate with whole blood clotting time for monitoring heparin treatment in patients with thrombo-embolic disease?
Does activated partial thromboplastin time correlate with whole blood clotting time for monitoring heparin treatment in patients with thrombo-embolic disease?
The activated partial thromboplastin time is a convenient and suitable test for the routine control of heparin therapy, showing good correlation with whole blood clotting time in most patients.
aPTT may support heparin monitoring in most patients; leaves open prospective validation and management of discrepant cases.
Summary The effect of heparin on the activated partial thromboplastin time and whole blood clotting time was measured in 30 patients with thrombo‐embolic disease. In 27 of these patients there was good correlation between the results of the two tests. Three patients showed little change of the activated partial thromboplastin time, although the clotting time was prolonged by heparin. It is uncertain at present which of these two tests provides the better measure of the antithrombotic effects of heparin when such a discrepancy exists. However, the activated partial thromboplastin time is more convenient to perform and we consider it to be the more suitable test for the routine control of heparin therapy.
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Hirsh et al. (1970) studied this question.
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