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November 1, 1980American Journal of Clinical Pathology

Heparin and the Activated Partial Thromboplastin Time — A Difference between theIn-vitroandIn-vivoEffects and Implications for the Therapeutic Range

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Why the study?

How does the in-vivo sensitivity of aPTT reagents to heparin compare to in-vitro sensitivity, and what are the implications for the therapeutic range?

Design

Other

Authors

BBBarbara J. BainSt Mary's HospitalTFTrevor ForsterPrince Charles HospitalBSBarbara SleighPrince Charles Hospital

Discussion

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Implication

May require reagent-specific aPTT ranges for heparin; leaves open prospective validation of clinical outcomes.

Structured PICO

How does the in-vivo sensitivity of aPTT reagents to heparin compare to in-vitro sensitivity, and what are the implications for the therapeutic range?

I
Intervention
Heparin monitoring using aPTT reagents
O
Outcome
Sensitivity of aPTT reagents to heparin (in-vivo vs in-vitro)surrogate

Highlights the variability in aPTT reagent sensitivity to heparin, emphasizing that a universal 1.5-2.5x therapeutic range is inappropriate for all reagents.

Cite This Study

Bain et al. (1980) studied this question.

synapsesocial.com/papers/6a702c7975498292b7098e1ehttps://doi.org/10.1093/ajcp/74.5.668
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis1977 · 182 citations
  2. 2THE MECHANISM OF CLOT DISSOLUTION BY PLASMIN*1959 · 574 citations
  3. 3A Prospective Study of the Value of Monitoring Heparin Treatment with the Activated Partial Thromboplastin Time1972 · 668 citations
  4. 4Comparative Evaluation of a Partial Thromboplastin Reagent Containing a Non-settling, Particulate Activator1974 · 41 citations