Key result
Heparin impaired antithrombin III inhibitory capacity, causing residual active thrombin accumulation when at least 1.5 to 2 units of thrombin per antithrombin III unit were present.
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May limit heparin efficacy in thrombin excess; leaves open clinical validation of antithrombin monitoring or supplementation.
Ewa Marciniak (1975) studied Thrombin-Antithrombin III Interaction. Heparin vs. Absence of heparin was evaluated on Inhibitory capacity of antithrombin III. Heparin impaired antithrombin III inhibitory capacity, causing residual active thrombin accumulation when at least 1.5 to 2 units of thrombin per antithrombin III unit were present.
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