What question did this study set out to answer?

To evaluate whether purified antithrombin III concentrate restores in vitro anticoagulation responsiveness measured by activated coagulation time in cardiac surgery patients receiving preoperative heparin.

May 1, 2000Anesthesia & Analgesia

The In Vitro Effects of Antithrombin III on the Activated Coagulation Time in Patients on Heparin Therapy

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Authors

JLJerrold H. LevyCardiac Surgery FMFélix R. MontesInstitute of Cardiology FSFania SzlamUniversity of Maryland, Baltimore

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Implication

In vitro study reveals that antithrombin III restores heparin sensitivity in cardiac surgery patients, suggesting targeted therapy can reverse heparin resistance.

Key Points

To evaluate whether purified antithrombin III concentrate restores in vitro anticoagulation responsiveness measured by activated coagulation time in cardiac surgery patients receiving preoperative heparin.
Blood samples were collected from 43 cardiac surgery patients, including 22 receiving preoperative heparin (mean duration 4.0 days, range 2–10 days) and 21 control patients not receiving heparin.
Samples were tested in vitro at heparin concentrations of 4.1, 5.4, and 6.8 U/mL, measuring kaolin-activated clotting times with and without 0.2 U/mL purified human antithrombin III concentrate.
Antithrombin activity was significantly depleted in patients receiving preoperative heparin compared to controls (69% ± 9% vs. 92% ± 8%, P < 0.01).
Heparin concentrations above 4.1 U/mL failed to produce any further prolongation of activated clotting times across all patient samples.
Supplementation with 0.2 U/mL of purified antithrombin III significantly prolonged the activated clotting time response to heparin in samples exhibiting heparin resistance.

Cite This Study

Levy et al. (2000) studied this question.

synapsesocial.com/papers/6a704c4f26a7f98052dccd52 https://doi.org/10.1097/00000539-200005000-00013

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Implication

In vitro study reveals that antithrombin III restores heparin sensitivity in cardiac surgery patients, suggesting targeted therapy can reverse heparin resistance.

The In Vitro Effects of Antithrombin III on the Activated Coagulation Time in Patients on Heparin Therapy

Discussion

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Implication

Key Points

Cite This Study

The In Vitro Effects of Antithrombin III on the Activated Coagulation Time in Patients on Heparin Therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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