Key result
Low and high heparin concentrations facilitate thrombin inactivation via distinct mechanisms including heparin co-factor.
Why the study?
The antithrombin activity of plasma, serum, and plasma fractions under different experimental conditions and heparin concentrations was not fully characterized.
Population
Normal plasma, serum, and plasma fractions
Comparison
Heparin at low concentration (~0.03 I.U./ml) vs high concentration (~2-15 I.U./ml) vs absence of heparin
Design
Experimental study using two assay methods for antithrombin activity
Authors
Loading...
Does not support clinical heparin dosing changes; leaves open distinct thrombin inactivation mechanisms for further study.
This basic science study characterizes the mechanisms of thrombin inactivation in plasma and serum, identifying the role of a heparin co-factor at high heparin concentrations.
Blombäck et al. (1963) studied this question. Heparin vs. Absence of heparin was evaluated on Inactivation of thrombin. Heparin at low concentrations (0.03 I.U./ml) and high concentrations (2-15 I.U./ml) facilitates thrombin inactivation in plasma and serum through distinct mechanisms, including heparin co-factor.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: