Conformational activation of antithrombin involves altered contacts of side chains of Tyr-131 and Ala-134 with core hydrophobic residues, with reactive center loop hinge expulsion playing a minor role.
No takes yet. Share an insight, caveat, or question.
Antithrombin variant boosts IXa/Xa inhibition without heparin in animals; leaves open heparin-independent anticoagulation strategies for human testing.
Dementiev et al. (2013) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: