February 20, 1998Biochemistry

Conformational Conversion of Antithrombin to a Fully Activated Substrate of Factor Xa without Need for Heparin

View Full Paper

Ask AI

Bookmark

Population

In vitro biochemical model (antithrombin variant)

Design

Preclinical

Authors

Discussion

Hypothesis-generating for antithrombin-targeted anticoagulants; leaves open in vivo translation and clinical utility.

Population

In vitro biochemical model (antithrombin variant)

Intervention

Replacement of serine at position 380 with cysteine and derivatization with fluorescein

Outcome

Activation toward reaction with factor Xasurrogate

This biochemical study establishes a structural basis for the mechanism of heparin activation of antithrombin against factor Xa.

Huntington et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark