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Double-stranded RNA (dsRNA) activates the sequence-specific degradation of homologous mRNAs in animal and plant cells by a process known as RNA interference (RNAi). The mediators of mRNA degradation are 21–23-nt small interfering ribonucleoprotein particles (siRNPs) which are produced from dsRNA by an RNase III-like processing reaction (see schematic picture). RNAi has rapidly become an invaluable tool for functional genomics and siRNAs are promising candidates for future biomedical applications.
Thomas Tuschl (Sun,) studied this question.