Key result
Surgery before 12 hours for hip fracture improved 30-day survival compared with surgery after 12 hours (p=0.013), while further delays did not significantly affect mortality.
Why the study?
Does surgery before 12 hours reduce 30-day mortality in patients aged > 60 years with a hip fracture?
Observational (n=6,638)
No
Does surgery before 12 hours reduce 30-day mortality in patients aged > 60 years with a hip fracture?
p-value: p=0.013
In patients over 60 years old with a hip fracture, surgery within 12 hours of admission significantly improves 30-day survival compared to surgery delayed beyond 12 hours.
Early surgery was associated with reduced 30-day mortality after hip fracture; leaves open whether randomized evidence would confirm benefit.
There has been extensive discussion about the effect of delay to surgery on mortality in patients sustaining a fracture of the hip. Despite the low level of evidence provided by many studies, a consensus has been accepted that delay of > 48 hours is detrimental to survival. The aim of this prospective observational study was to determine if early surgery confers a survival benefit at 30 days. Between 1989 and 2013, data were prospectively collected on patients sustaining a fracture of the hip at Peterborough City Hospital. They were divided into groups according to the time interval between admission and surgery. These thresholds ranged from < 6 hours to between 49 and 72 hours. The outcome which was assessed was the 30-day mortality. Adjustment for confounders was performed using multivariate binary logistic regression analysis. In all, 6638 patients aged > 60 years were included. Worsening American Society of Anaesthesiologists grade (p < 0.001), increased age (p < 0.001) and extracapsular fracture (p < 0.019) increased the risk of 30-day mortality. Increasing mobility score (p = 0.014), mini mental test score (p < 0.001) and female gender (p = 0.014) improved survival. After adjusting for these confounders, surgery before 12 hours improved survival compared with surgery after 12 hours (p = 0.013). Beyond this the increasing delay to surgery did not significantly affect the 30-day mortality.
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Bretherton et al. (2015) conducted an observational in Fracture of the hip (n=6,638). Surgery before 12 hours vs. Surgery after 12 hours was evaluated on 30-day mortality (p=0.013). Surgery before 12 hours for hip fracture improved 30-day survival compared with surgery after 12 hours (p=0.013), while further delays did not significantly affect mortality.
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