Key result
Arterial hypertension in middle age negatively affects late-life cognitive function, while antihypertensive therapy shows a positive effect on preventing cognitive impairment and dementia.
Why the study?
Does antihypertensive therapy prevent cognitive impairment and dementia in patients with arterial hypertension?
Does antihypertensive therapy prevent cognitive impairment and dementia in patients with arterial hypertension?
Antihypertensive therapy appears to have a protective effect against cognitive impairment and dementia, highlighting the need for interdisciplinary management of hypertension.
Hypertension may raise dementia risk from midlife; leaves open need for RCTs on BP targets for cognition.
This article presents a review of Russian and foreign literature about the impact of arterial hypertension (AH) on the risk of cognitive impairment and dementia. Large studies have demonstrated the effect of blood pressure (BP) on the risk of vascular dementia and Alzheimer's disease (AD) in elderly and oldest old people as well as a role of antihypertensive therapy. There is evidence of a negative effect of hypertension in middle age on cognitive functions in late-life. Observational studies as a whole have shown the positive effect of antihypertensive therapy on the prevention of cognitive function and dementia. However, there are a number of limitations that dictate the need for further research on this issue. The importance of the interdisciplinary approach to treatment of cognitive impairment by cardiologists and/or therapists, together with neurologists, as well as complex treatment regimens, including correction of risk factors and neuroprotective therapy, is highlighted.
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Остроумова et al. (2018) conducted a review in Arterial hypertension, cognitive impairment, and dementia. Arterial hypertension and antihypertensive therapy was evaluated. Arterial hypertension in middle age negatively affects late-life cognitive function, while antihypertensive therapy shows a positive effect on preventing cognitive impairment and dementia.
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