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April 1, 2001The Journal of PhysiologyOpen Access

Modulation of rat erg1, erg2, erg3 and HERG K+ currents by thyrotropin‐releasing hormone in anterior pituitary cells via the native signal cascade

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Key result

Thyrotropin-releasing hormone significantly reduced the maximal available erg current amplitude by 12% (erg1), 13% (erg2), and 39% (erg3) in GH3/B6 cells.

Population

Clonal somatomammotroph GH3/B6 cells injected with cDNA coding for rat erg1, erg2, erg3 and HERG K+ channels

Design

Preclinical

Authors

WSWiebke SchledermannUniversität HamburgIWIris WulfsenUniversität HamburgJSJürgen R. SchwarzUniversität Hamburg

Discussion

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Implication

May modulate pituitary and cardiac excitability; leaves open translational relevance to human HERG-related arrhythmias.

Structured PICO

P
Population
Clonal somatomammotroph GH3/B6 cells injected with cDNA coding for rat erg1, erg2, erg3 and HERG K+ channels
I
Intervention
Thyrotropin-releasing hormone (TRH) (1 M)
O
Outcome
Modulation of erg K+ currents (voltage dependence of activation, maximal available current amplitude, deactivation kinetics)surrogate

TRH modulates all three members of the erg channel subfamily (including HERG) in GH3/B6 cells via an unidentified signaling pathway.

Cite This Study

Schledermann et al. (2001) studied this question. Thyrotropin-releasing hormone (TRH) was evaluated on erg K+ current modulation. Thyrotropin-releasing hormone significantly reduced the maximal available erg current amplitude by 12% (erg1), 13% (erg2), and 39% (erg3) in GH3/B6 cells.

synapsesocial.com/papers/6a6510f2dfe9f9fc9bef43c9https://doi.org/10.1111/j.1469-7793.2001.0143g.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Modulation of human erg K+ channel gating by activation of a G protein‐coupled receptor and protein kinase C1998 · 89 citations
  2. 2Identification of Two Nervous System-Specific Members of theergPotassium Channel Gene Family1997 · 238 citations
  3. 3Fast inactivation causes rectification of the IKr channel.1996 · 397 citations
  4. 4MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia1999 · 1,363 citations
  5. 5The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.1990 · 82 citations