Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 15, 1997

Identification of two nervous system-specific members of the erg potassium channel gene family.

View Full Paper
Ask AI
Bookmark
Share

Population

Rat nervous system (preclinical model)

Comparison

Identification and characterization of erg2 and… vs erg1 (HERG) gene

Design

Preclinical

Authors

WSWenmei ShiHohai UniversityRWRandy S. WymoreOklahoma State University Center for Health SciencesHWHongsheng WangSun Yat-sen University

Discussion

Loading...

Member takes

Implication

Does not change LQT2 management; hypothesis-generating for erg channel roles in sympathetic and neural function.

Structured PICO

P
Population
Rat nervous system (preclinical model)
I
Intervention
Identification and characterization of erg2 and erg3 potassium channel genes
C
Comparator
erg1 (HERG) gene
O
Outcome
Gene expression patterns and electrophysiological propertiessurrogate

The identification of nervous system-specific erg2 and erg3 genes and the expression of erg1 in the sympathetic nervous system may have implications for understanding the etiology of LQT2 long QT syndrome.

Cite This Study

Shi et al. (1997) studied this question.

synapsesocial.com/papers/6a77dd34576efb0ddaf7b14ehttps://doi.org/10.1523/jneurosci.17-24-09423.1997
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The<i>Drosophila erg</i>K<sup>+</sup>Channel Polypeptide Is Encoded by the Seizure Locus1997 · 110 citations
  2. 2Potassium Channel mRNA Expression in Prevertebral and Paravertebral Sympathetic Neurons1996 · 50 citations
  3. 3A HERG‐like K+ channel in rat F‐11 DRG cell line: pharmacological identification and biophysical characterization.1996 · 100 citations
  4. 4A family of potassium channel genes related to eag in Drosophila and mammals.1994 · 991 citations
  5. 5Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats.1994 · 304 citations