Key result
The erg-like K+ current in native rat lactotrophs consists of fast and slowly deactivating components, differing from clonal GH3/B6 cells, and is reduced by thyrotrophin-releasing hormone.
Population
Rat lactotrophs from primary culture and clonal rat pituitary cells (GH3/B6)
Design
Preclinical
Authors
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Should not change clinical practice; extends erg channel characterization from clonal to native rat lactotrophs.
This study characterizes the electrophysiological and molecular properties of erg-like potassium channels in rat lactotrophs, highlighting differences in current components and mRNA expression compared to clonal pituitary cells.
Schäfer et al. (1999) studied this question. E-4031 and Thyrotrophin-releasing hormone was evaluated on erg-like K+ current characteristics. The erg-like K+ current in native rat lactotrophs consists of fast and slowly deactivating components, differing from clonal GH3/B6 cells, and is reduced by thyrotrophin-releasing hormone.
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