Population
Three rat erg channels (erg1, erg2, erg3) heterologously expressed in CHO cells
Comparison
Increase in extracellular K+ concentration to 10… vs Baseline extracellular K+ concentration of 2 mM
Design
Preclinical
Authors
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Conserved K+ sensitivity across rat erg channels; leaves open translation to human cardiac repolarization in altered extracellular potassium.
Extracellular potassium-dependent changes in biophysical properties are conserved across the rat erg K+ channel family, which has implications for understanding channel behavior during physiological and pathophysiological changes in local potassium concentrations.
Sturm et al. (2005) studied this question.
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