Population
Xenopus oocytes expressing transient outward potassium channels
Comparison
Elevating extracellular potassium ([K]o) vs Baseline/normal extracellular potassium
Design
Preclinical
Authors
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May influence Ito in hyperkalemia via inactivation-specific mechanisms; leaves open translation to human cardiac electrophysiology.
The effects of elevating extracellular potassium on transient outward potassium channels vary significantly depending on the specific inactivation mechanism (N-type vs. C-type) of the channel.
Tseng et al. (1992) studied this question.
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