What question did this study set out to answer?

This study investigates the effect of thrombin on phosphatidylinositol 4,5-bisphosphate levels in platelets.

November 1, 1982Journal of Biological ChemistryOpen Access

Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

View Full Paper

Ask AI

Bookmark

Authors

MBMotasim BillahMerck & Co., Inc., Rahway, NJ, USA (United States)ELE G LapetinaUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Randomized trial finds thrombin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate in platelets, indicating its role in platelet activation.

Key Points

This study investigates the effect of thrombin on phosphatidylinositol 4,5-bisphosphate levels in platelets.
Horse platelets were prelabeled with 32P and stimulated with thrombin.
Radioactive measurements were taken to assess the degradation of phosphatidylinositol 4,5-bisphosphate.
The effect of the calcium ionophore A23187 was evaluated for comparison.
A rapid decrease of 15-20% in phosphatidylinositol 4,5-bisphosphate was observed after 10 seconds of thrombin stimulation.
No significant change in phosphatidylinositol 4-monophosphate was noted during this time.
The loss of phosphatidylinositol 4,5-bisphosphate was concentration-dependent upon thrombin stimulation.

Cite This Study

Billah et al. (1982) studied this question.

synapsesocial.com/papers/6a6510fbdfe9f9fc9bef43f6 https://doi.org/10.1016/s0021-9258(18)33568-3

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial finds thrombin induces rapid degradation of phosphatidylinositol 4,5-bisphosphate in platelets, indicating its role in platelet activation.

Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

Discussion

Member takes

Implication

Key Points

Cite This Study

Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider