Mitochondrial uncoupling is reviewed as a potential underlying mechanism for reduced cardiac efficiency and increased myocardial oxygen consumption in the diabetic and obese heart.
Mitochondrial uncoupling may play a key role in the reduced cardiac efficiency observed in obesity and diabetes.
Cardiovascular disease is the primary cause of death in individuals with obesity and diabetes. However, the underlying mechanisms for cardiac dysfunction are partially understood. Studies have suggested that altered cardiac metabolism may play a role. The diabetic heart is characterized by increased fatty acid oxidation, increased myocardial oxygen consumption, and reduced cardiac efficiency. Here, we review possible mechanisms for reduced cardiac efficiency in obesity and diabetes by focusing on the potential role of mitochondrial uncoupling.
Boudina et al. (Tue,) conducted a review in Obesity and diabetes. Mitochondrial uncoupling was evaluated. Mitochondrial uncoupling is reviewed as a potential underlying mechanism for reduced cardiac efficiency and increased myocardial oxygen consumption in the diabetic and obese heart.